Prevalence and Molecular Identification of Human Schistosomiasis With Assessment of Associated Epidemiological Risk Factors in Assiut Governorate, Egypt
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 359
- 主要终点
- prevalence of human schistosomiasis in the study participants
研究概览
简要总结
Schistosomiasis remains one of the most important parasitic diseases of public health concern, particularly in developing countries including Egypt. It is caused by a trematode worm (blood flukes) of the genus Schistosoma
详细描述
Schistosomiasis has been diagnosed in Egypt since pharaonic times (3200 B.C.) by recovering Schistosome eggs and antigens in ancient mummies.In Egypt, Schistosoma mansoni and Schistosoma haematobium have historically been highly endemic, with widespread distribution along the Nile Delta and Valley.(4) Schistosoma haematobium is responsible for urogenital schistosomiasis, with hematuria as its primary manifestation, while Schistosoma mansoni, the prevalent species in Egypt, is causing intestinal schistosomiasis with liver-related sequelae
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged ≥ 5 years of both sexes attending Assiut Governorate hospitals during the study period.
- •Patients clinically suspected of having schistosomiasis (urinary and/or intestinal) or referred for parasitological examination.
- •Individuals (or guardians, in case of minors) who provide written informed consent.
- •Patients willing to provide the required biological samples (urine and/or stool).
排除标准
- •Patients Received praziquantel within the last 3 months before sample collection
- •Patients with incomplete clinical or epidemiological data.
- •Patients refusing participation or sample collection.
- •Improperly collected, contaminated, or insufficient samples.
- •Patients suffering from severe comorbid conditions that may interfere with the interpretation of results (e.g., advanced hepatic or renal failure).
- •children with congenital urinary or intestinal anomalies.
研究组 & 干预措施
Schistosoma haematobium
Urine filtration technique (10 ml urine) for diagnosis
干预措施: Molecular phylogenetic and haplotype analysis (Diagnostic Test)
Schistosoma mansoni
Direct wet mount and Kato-Katz thick smear technique (stool) for diagnosis
干预措施: Molecular phylogenetic and haplotype analysis (Diagnostic Test)
结局指标
主要结局
prevalence of human schistosomiasis in the study participants
时间窗: 24 hours
using conventional microscopic examination
次要结局
未报告次要终点
研究者
Intesar Heshmat Yousef
Principial investigator
Assiut University