Diet Oil Induced Stimulation of GLP-1
Trial Snapshot
- Phase
- Phase 1
- Status
- Completed
- Sponsor
- University of Copenhagen
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Plasma GLP-1
Study Overview
Brief Summary
Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone.
Detailed Description
Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone. The aim of the study is to elucidate the effect of 2-OG, 'diet oil' on GLP-1 secretion in patients with type 2 diabetes and to explain the mechanism behind the known stimulation of GLP-1 release by dietary fat.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with type 2 diabetes mellitus according to the WHO criteria
- •caucasians
- •age above 18 years
- •BMI 20-30
Exclusion Criteria
- •kidney disease
- •liver disease
- •retinopathy
- •use of insulin
- •use of GLP-1 analogues
- •use of DPP-4 inhibitors
Arms & Interventions
Diet oil
Intervention: Diet oil (Dietary Supplement)
Carrot
Intervention: Carrot (Dietary Supplement)
Olive oil
Intervention: Olive oil (Dietary Supplement)
Outcomes
Primary Outcomes
Plasma GLP-1
Time Frame: 3 hours
Glp-1 response is measured during and three hours after ingestion of the different mealtest
Secondary Outcomes
- Plasma insulin(3 hours)
- Plasma glucose(3 hours)
- Plasma GIP(3 hours)
- Plasma glucagon(3 hours)
- Plasma PYY(3 hours)
- Plasma paracetamol(3 hours)
Investigators
Katrine Bagge Hansen
MD
University of Copenhagen