Diet Oil Induced Stimulation of GLP-1
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Plasma GLP-1
研究概览
简要总结
Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone.
详细描述
Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone. The aim of the study is to elucidate the effect of 2-OG, 'diet oil' on GLP-1 secretion in patients with type 2 diabetes and to explain the mechanism behind the known stimulation of GLP-1 release by dietary fat.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with type 2 diabetes mellitus according to the WHO criteria
- •caucasians
- •age above 18 years
- •BMI 20-30
排除标准
- •kidney disease
- •liver disease
- •retinopathy
- •use of insulin
- •use of GLP-1 analogues
- •use of DPP-4 inhibitors
结局指标
主要结局
Plasma GLP-1
时间窗: 3 hours
Glp-1 response is measured during and three hours after ingestion of the different mealtest
次要结局
- Plasma insulin(3 hours)
- Plasma glucose(3 hours)
- Plasma GIP(3 hours)
- Plasma glucagon(3 hours)
- Plasma PYY(3 hours)
- Plasma paracetamol(3 hours)
研究者
Katrine Bagge Hansen
MD
University of Copenhagen