Diet Oil Induced Stimulation of GLP-1

Early Phase 1

Completed

• Conditions: Type 2 Diabetes Mellitus
• Interventions: Dietary Supplement: Diet oil; Dietary Supplement: Olive oil; Dietary Supplement: Carrot

• Registration Number: NCT01453842
• Lead Sponsor: University of Copenhagen

Brief Summary

Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone.

Detailed Description

Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone. The aim of the study is to elucidate the effect of 2-OG, 'diet oil' on GLP-1 secretion in patients with type 2 diabetes and to explain the mechanism behind the known stimulation of GLP-1 release by dietary fat.

Study Timeline

• Study Start: 2011-03
• Study First Submitted: 2011-10-13
• Study First Submitted QC: 2011-10-17
• Study First Posted: 2011-10-18
• Primary Completion: 2011-12
• Study Completion: 2012-03
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-01
• Last Update Posted: 2014-12-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Patients with type 2 diabetes mellitus according to the WHO criteria
• caucasians
• age above 18 years
• BMI 20-30

Exclusion Criteria

• kidney disease
• liver disease
• retinopathy
• anaemia
• use of insulin
• use of GLP-1 analogues
• use of DPP-4 inhibitors

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Diet oil	Diet oil	-
Olive oil	Olive oil	-
Carrot	Carrot	-

Primary Outcome Measures

Name	Time	Method
Plasma GLP-1	3 hours	Glp-1 response is measured during and three hours after ingestion of the different mealtest

Secondary Outcome Measures

Name	Time	Method
Plasma insulin	3 hours	Plasma insulin is measured during and 3 hours after mealtest
Plasma glucose	3 hours	Plasma glucose is measured during and 3 hours after meal test
Plasma GIP	3 hours	Plasma GIP is measured during and 3 hours after meal test
Plasma glucagon	3 hours	Plasma glucagon is measured during and 3 hours after meal test
Plasma PYY	3 hours	Plasma PYY is measured during and 3 hours after meal test
Plasma paracetamol	3 hours	Plasma paracetamol is measured during and 3 hours after meal test

Trial Locations

Locations (1)

Department of Clinical Physiology; 🇩🇰 Glostrup, Denmark