Perifollicular Doppler in Natural Cycle In Vitro Fertilization

Completed

• Conditions: Infertility
• Interventions: Procedure: Doppler ultrasound

• Registration Number: NCT01668212
• Lead Sponsor: Clinique Ovo

Brief Summary

Perifollicular Doppler could reflect the quality of the follicle's vascularization and, consequently, the one of the oocyte that ensues from it. Perifollicuar Doppler is the analysis, in ultrasound, of the blood flow in vessels surrounding the follicle.

The goal of this study is to evaluate if there is a link, in natural cycle In Vitro Fertilization, between the quality of the vascularization and the one of the oocyte, the embryo and the pregnancy.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Study First Submitted: 2012-06-19
• Study First Submitted QC: 2012-08-14
• Study First Posted: 2012-08-20
• Primary Completion: 2013-05
• Status Verified: 2013-06
• Last Update Submitted: 2013-06-21
• Last Update Posted: 2013-06-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 160

Inclusion Criteria

• Patient with a natural In Vitro Fertilization cycle.
• Patient under 38 years old
• Body mass indice under 35
• Ovulatory cycles between 20-35 days

Exclusion Criteria

• Patient with a stimulation In Vitro Fertilization cycle
• Patient with a naturalIn Vitro Fertilization cycle with egg donor
• Patient with a natural In Vitro Fertilization cycle with freezing embryo
• Smoking patient
• Diabetic patient
• Patient with treatment of antihypertensive drug, anticoagulant, antiplatelet, vasodilator
• Body mass indice over 35
• Patient over 38 years old
• Patient without ovulation or cycle over 35 days
• Percutaneous Epididymal Sperm Aspiration (PESA), Testicular Sperm Extraction (TESE) or micro TESE

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
natural In Vitro Fertilization cycle	Doppler ultrasound	Patient doing following natural In Vitro fertilization cycle

Primary Outcome Measures

Name	Time	Method
Quality perifollicular doppler and quality of the oocyte	2 weeks	The measurements are done twice; on days of induction and oocyte retrieval. During the blood sample collection on the day of the induction, there is also a measurement of progesterone, estradiol and luteinizing hormone (LH).

Trial Locations

Locations (1)

Ovo Fertilité; 🇨🇦 Montréal, Quebec, Canada