Evaluation of Oxygen Therapy Delivery Systems in Hypoxemic Acute Respiratory Failure
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Nantes University Hospital
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Calcul of the ratio PaO2/FiO2
Study Overview
Brief Summary
The main objective of this study is to evaluate the efficiency of the oxygen therapy delivery system Optiflow® compared to 2 others standard oxygen therapy delivery systems (Ospal®, non invasive ventilation).12 immunocompetent patients will compare the successive use of oxygen therapy delivery systems Optiflow®/Ospal® and 12 immunodeficient patients will compare the successive use of systems Optiflow®/Non invasive ventilation.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patient hospitalized in the intensive care unit of Nantes University Hospital
- •Signed informed consent
- •Patient with not hypercapnic acute hypoxemic respiratory failure
- •Immunocompetent and immunodeficient patient
Exclusion Criteria
- •Age < 18 years
- •Pregnancy
- •Contra-indication to non invasive ventilation
- •Allergy to xylocaine
- •Coagulation troubles
- •Tracheotomized patient
- •Urgent indication to intubation
- •Hypercapnic acute respiratory failure
- •Acute pulmonary edema
- •Face or nose malformation
Arms & Interventions
VNI/Optiflow, Immunodeficient patients
VNI = non invasive ventilation
Intervention: Oxygen therapy delivery systems (Other)
Optiflow/VNI, Immunodeficient patients
VNI = non invasive ventilation
Intervention: Oxygen therapy delivery systems (Other)
Ospal/Optiflow, Immunocompetent patients
Intervention: Oxygen therapy delivery systems (Other)
Optiflow/Ospal, Immunocompetent patients
Intervention: Oxygen therapy delivery systems (Other)
Outcomes
Primary Outcomes
Calcul of the ratio PaO2/FiO2
Time Frame: one hour after each system used
The main objective of this study is to evaluate the efficiency of the oxygen therapy delivery system Optiflow® compared to 2 others standard oxygen therapy delivery systems (Ospal®, non invasive ventilation) by calculating the ratio PaO2/FiO2
Secondary Outcomes
- number of participants with adverse events
- measure of respiratory frequency and blood gas
- measure of positive and expiratory pressure