Cardiac Injury in Patients With Influenza

Active, not recruiting

• Conditions: Myocardial Injury; Influenza, Human

• Registration Number: NCT03339180
• Lead Sponsor: Örebro University, Sweden

Brief Summary

This study investigate the prevalence of elevated biomarkers of cardiac injury in patients with suspected influenza infection and the prognostic implication on the composite endpoint of death of any cause, hospitalization due to myocardial infarction, unstable angina, heart failure and stroke.

Detailed Description

The relationship between influenza and cardiovascular events was described in an early study of influenza epidemics from 1915 to 1929 including the 1918-1920 pandemic. Retrospective studies have shown increased risk for acute myocardial infarction (AMI) during the first week following an infection with influenza.

Biochemical markers of cardiac injury such as high sensitive cardiac troponins may be increased during infection with influenza. Increased levels of cardiac troponins are associated with adverse outcome in many different populations.

Study Timeline

• Study Start: 2017-10-01
• Study First Submitted: 2017-10-26
• Study First Submitted QC: 2017-11-07
• Study First Posted: 2017-11-13
• Primary Completion: 2022-04-30
• Status Verified: 2022-09
• Last Update Submitted: 2022-09-20
• Last Update Posted: 2022-09-21
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 466

Inclusion Criteria

• Adult patients (>18 years) presenting with influenza-like illness.
• Written informed consent.

Exclusion Criteria

• Inability to provide informed consent.
• Age <18 years.
• Symptoms indicating an acute coronary syndrome, acute heart failure, rapid atrial fibrillation or acute stroke.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Level of biochemical markers	One year	Level of other biochemical markers in patients with influenza

Secondary Outcome Measures

Name	Time	Method
Prognostic implication	One year	Time to admission for stroke

Trial Locations

Locations (1)

Örebro University; 🇸🇪 Örebro, Sweden