Omega-3 fatty acids and mild cognitive impairment in older adults

Phase 1

Completed

• Conditions: Depression; Mild cognitive impairment in older adults; Mental Health - Studies of normal psychology, cognitive function and behaviour; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12609000167268
• Lead Sponsor: utritional Physiology Research Centre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-04-03
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Mild cognitive impairment (subjective memory loss over past 6 months; Standardised Mini-Mental State Examination (SMMSE) score > 24; Paired Associate Learning (PAL) score < 1.5 standard deviations from population mean and/or Demtect score between 9-12)

Exclusion Criteria

Dementia and other neurological conditions, consumption of omega-3 fatty supplements within previous 3 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean score on the Rey Auditory Verbal Learning Test (RAVLT) assessing recall and delayed recall memory[Baseline and 6-months];Mean Geriatric Depression Scale score[Baseline and 6 months]

Secondary Outcome Measures

Name	Time	Method
Mean score on Initial and Excluded Letter Fluency[Baseline and 6 months];Mean score on the Trail Making Task[Baseline and 6 months];Mean score on Digit Span Forward and Backward[Baseline and 6 months];Mean score on Letter-number Sequencing[Baseline and 6 months];Cerebral blood vessel reactivity - transcranial Doppler sonography (tcD)[Baseline and 6 months];Total L-homocysteine, B12 and folate, measured from blood plasma using a Chemiluminescent Microparticle Immunoassay[Baseline and 6 months];Telomere length, measured by quantitative real-time polymerase chain reaction (PCR) using deoxyribonucleic acid (DNA) isolated from peripheral blood[Baseline and 6 months];Phospholipase A2 (PLA2) activity, assessed using high performance thin layer chromatography and quantitative imaging of resulting fluorescent spots[Baseline and 6 months];Mean Memory Functioning Questionnaire score[Baseline and 6 months];Mean score on the Stroop colour-word test[Baseline and 6 months];SF-36 Health Survey[Baseline and 6 months]