Assess the efficacy of multitarget therapy in prevention of Avascular necrosis (AVN)
Phase 3
- Conditions
- Osteonecrosis.
- Registration Number
- IRCT20210808052105N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
Patients with autoimmune connective tissue diseases and vasculitis
Requires treatment with high doses of corticosteroids
Exclusion Criteria
Co-occurrence of antiphospholipid syndrome
Taking drugs that increase the risk of coagulation, such as oral contraceptives
Occurrence of events leading to increased coagulation such as long-term hospitalization, trauma leading to surgery
Taking anticoagulants
Occurrence of adverse drug reactions in the course of patient examination
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evidence of Osteonecrosis following high-dose Corticosteroids. Timepoint: In the first three months after starting Corticosteroid and also one year after starting it. Method of measurement: Three-phasic bone scan.
- Secondary Outcome Measures
Name Time Method Incidence of side effects of drugs. Timepoint: Monthly. Method of measurement: History and Laboratory findings.