Phytoestrogens as an Alternative to Estradiol in Reversing the Antiestrogenic Effect of Clomid on Endometrium in Ovulation Induction in Cases of Polycystic Ovarian Syndrome
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 150
- 主要终点
- endometrial thickness
研究概览
简要总结
Prospective study conducted on 150 women with polycystic ovarian syndrome (PCOS) were randomly divided into 3 groups: group I (50 women) received clomiphene citrate (CC) only 50 mg orally every 8 hours started from cycle day 3 for 5 days, group II (50 women) received 2mg estradiol valerate daily from cycle day 7 - 11 in addition to CC and group III (50 women) received phytoestrogen (20mg of cimifuga racemosa from day 1- 12) in addition to CC.
详细描述
Prospective study conducted on 150 women with PCOS were randomly divided into 3 groups: group I (50 women) received CC only50 mg orally every 8 hours started from cycle day 3 for 5 days, group II (50 women) received 2mg estradiol valerate daily from cycle day 7 - 11 in addition to CC and group III (50 women) received phytoestrogen (20mg of cimifuga racemosa from day 1- 12) in addition to CC.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 37 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women with both 1ry and 2ry infertility were included. All women were between 20 and 37 years old.
排除标准
- •women with endocrinological abnormalities as thyroid dysfunction or abnormal prolactin levels, those with hypothalamic or pituitary dysfunctions evaluated by low gonadotropin level, other causes of infertility as tubal factor evaluated by HSG or laparoscopy, abnormal uterine cavity evaluated by sonohystrography or hysteroscopy and male factor evaluated by semen analysis. Women with ovarian cysts were also excluded from the study
研究组 & 干预措施
clomiphene citrate
only50 mg orally every 8 hours started from cycle day 3 for 5 days
干预措施: clomiphene citrate (Drug)
estradiol valerate and CC
2mg estradiol valerate orally daily from cycle day 7 - 11 in addition to CC
干预措施: estradiol valerate (Drug)
estradiol valerate and CC
2mg estradiol valerate orally daily from cycle day 7 - 11 in addition to CC
干预措施: clomiphene citrate (Drug)
Phytoestrogen and CC
20mg of cimifuga racemosaorally from day 1- 12) in addition to CC
干预措施: phytoestrogen (Drug)
Phytoestrogen and CC
20mg of cimifuga racemosaorally from day 1- 12) in addition to CC
干预措施: clomiphene citrate (Drug)
结局指标
主要结局
endometrial thickness
时间窗: day 14 of menstrual cycle
次要结局
未报告次要终点
研究者
Ahmed Maged
Assistant professor
Cairo University