NCT01010919已完成1 期
A Phase I Study of Chicory for Treatment of Osteoarthritis of the Hip or Knee
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
研究概览
简要总结
Extracts of chicory root have anti-inflammatory properties in vitro and in animal models of arthritis. The primary objective of this investigator-initiated, Phase 1, placebo-controlled, double blind, dose-escalating trial is to determine the safety and tolerability of a proprietary bioactive extract of chicory root in patients with osteoarthritis (OA). Secondary objectives are to assess effects on the signs and symptoms of this disorder. Individuals greater than 50 years of age with OA of the hip or knee will be eligible for trial entry.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients must be 50 years of age or older and may be of either gender.
- •Patients must have have an imaging-confirmed (radiograph or MRI) diagnosis of OA of the hip or knee.
- •Patients must not have taken a nonsteroidal anti-inflammatory medication for at least 7 days prior to the baseline visit (a single daily aspirin 325 mg or less is allowed throughout the study).
- •Patients must be able and willing to give informed consent.
排除标准
- •Any unstable comorbid medical condition that in the opinion of the investigator could interfere with the ability of the patient to complete the study.
- •Patients who are unable to ambulate and require a wheelchair due to the severity of the arthritis are excluded. Ambulatory aids such as canes and walkers are acceptable.
- •Patients requiring continuing therapy with nonsteroidal anti-inflammatory drugs are excluded.
- •Patients requiring any dose of glucocorticoids within the past 30 days are excluded.
研究者
相似试验
尚未招募
不适用
Dried Chicory Root in IBDInflammatory Bowel DiseasesDietary ExposureNCT06016322University Medical Center Groningen12
尚未招募
不适用
The effect of dried chicory root on inflammation, gut microbiota and complaints in patients with Inflammatory Bowel Disease: a pilot study10017969Crohn's diseaseIBDNL-OMON56552niversitair Medisch Centrum Groningen12
已完成
2 期
Colchicine for Symptom and Inflammation in Knee OsteoarthritisKnee OsteoarthritisNCT02176460Singapore General Hospital109
招募中
3 期
Investigating the effect of chicory on fatty liveron-alcoholic fatty liver disease.Fatty (change of) liver, not elsewhere classified Nonalcoholic fatty liver disease [NAFLD]K76.0IRCT20231025059862N3Gorgan University of Medical Sciences220
已完成
2 期
The Effect of Equol for Hand Osteoarthritis in Perimenopausal WomeHand OsteoarthritisJPRN-jRCTs051190066Shimoe Takashi148