Task-oriented Training on Hand Function in Taxanes-induced Peripheral Neuropathy

Not Applicable

Completed

• Conditions: Peripheral Neuropathy; Chemotherapy Effect; Hand Function
• Interventions: Other: Task oriented training exercises; Other: Traditional physical therapy

• Registration Number: NCT06632626
• Lead Sponsor: Cairo University

Brief Summary

Chemotherapy based on taxanes is commonly used to treat breast cancer. However, chemotherapy-induced peripheral neuropathy (CIPN), a side effect of taxanes, impairs a patient's grip strength, hand dexterity, and upper extremity function which affects quality of life (QOL).

Detailed Description

Task-oriented training, a type of exercise where exercises are organized into tasks, concentrates on enhancing particular functional abilities through useful, goal-directed activities. So, the purpose of the study to explore the effectiveness of task-oriented training (TOT) on grip strength, hand dexterity and upper extremity function in patients with taxanes-induced peripheral neuropathy.

Study Timeline

• Study Start: 2023-09-01
• Primary Completion: 2024-04-01
• Study Completion: 2024-06-01
• Status Verified: 2024-10
• Study First Submitted: 2024-10-07
• Study First Submitted QC: 2024-10-07
• Study First Posted: 2024-10-09
• Last Update Submitted: 2024-10-16
• Last Update Posted: 2024-10-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• Patients were females only.
• Their ages range from 35 to 65.
• All patients suffered from CIPN after using taxanes (anti-cancer agent causing neurotoxic effect).
• Diagnosis of CIPN was determined based on symptom history or the presence of stocking glove pattern "distal dysesthesias, pain and numbness" beginning after taxanes intake.
• All patients enrolled to the study had their informed consent.
• Patients suffer from affected brachial plexus.

Exclusion Criteria

• Patients had pain or numbness in the upper extremity due to other reasons like trauma (fracture), CNS diseases (cerebral infarction), other diseases with neurological symptoms like (diabetes, rheumatoid arthritis or cervical myelopathy).
• Patients had bone, brain or spinal cord metastases.
• Patients who had history of psychiatric disorders like: depression and schizophrenia or cognitive decline that may hinder them from active participation in the study.
• Patients exhibited only acute neuropathy like in patients using oxaliplatin.

Exclusion Criteria:

• Patients had pain or numbness in the upper extremity due to other reasons like trauma (fracture), CNS diseases (cerebral infarction), other diseases with neurological symptoms like (diabetes, rheumatoid arthritis or cervical myelopathy).
• Patients had bone, brain or spinal cord metastases.
• Patients who had history of psychiatric disorders like: depression and schizophrenia or cognitive decline that may hinder them from active participation in the study.
• Patients exhibited only acute neuropathy like in patients using oxaliplatin

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Task oriented training group	Traditional physical therapy	This group included 30 patients suffering from taxanes induced peripheral neuropathy who received 30 minutes of task-oriented exercises, three sessions per week for four weeks along with 30 minutes of the traditional physical therapy.
Task oriented training group	Task oriented training exercises	This group included 30 patients suffering from taxanes induced peripheral neuropathy who received 30 minutes of task-oriented exercises, three sessions per week for four weeks along with 30 minutes of the traditional physical therapy.
Traditional physical therapy group	Traditional physical therapy	This group included 30 patients suffering from taxanes induced peripheral neuropathy who received 30 minutes of the traditional physical therapy only, three sessions per week for four weeks.

Primary Outcome Measures

Name	Time	Method
Hand grip strength	At baseline and after four weeks of intervention.	Hand grip strength (HGS) was measured in the dominant hand for each patient using The CAMRY dynamometer
Hand dexterity	At baseline and after four weeks of intervention.	The nine-hole peg test was used to assess the hand dexterity
Hand function	At baseline and after four weeks of intervention.	Each patient was asked to answer the questions of the six scales in the Arabic version of Michigan hand questionnaire (1- Overall hand function, 2-Activities of Daily Living, 3- Work performance, 4- Pain, 5- Aesthetics, and 6- Satisfaction with hand function)

Trial Locations

Locations (1)

faculty of physical therapy, Cairo university; 🇪🇬 Giza, Egypt