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Clinical Trials/NCT06462976
NCT06462976
Recruiting
Not Applicable

The Effect of Intraoperative Position and Mechanical Power on Postoperative Pulmonary Complications in Adult PNL(Percutaneous Nephrolithotomy) Patients

TC Erciyes University1 site in 1 country200 target enrollmentJuly 1, 2025

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Postoperative Pulmonary Complication
Sponsor
TC Erciyes University
Enrollment
200
Locations
1
Primary Endpoint
mechanical power
Status
Recruiting
Last Updated
9 months ago

Overview

Brief Summary

The aim of this study is to investigate the effect of different surgical positions (supine/prone) on lung mechanical power (MP) and its relationship with postoperative pulmonary complications in patients planned to percutaneous nephrolithotomy (PNL) under general anesthesia.

Detailed Description

PNL is the preferred treatment method for kidney stones larger than 2 cm, multiple kidney stones and staghorn stones. With new developments in the field of medicine, PNL has become a minimally invasive method and is preferred to open surgery in the treatment of kidney stones. Alternative types of anesthesia and various patient positions have been described in PNL. Mechanical power of ventilation (MP) is the amount of energy transferred from the mechanical ventilator to the respiratory system per unit time. Although this energy is primarily used to overcome airway resistance and respiratory system compliance, some of it acts directly on lung tissue, potentially causing ventilator-induced lung injury (VILI). Mechanical power during ventilation estimates the energy delivered to the respiratory system by integrating inspiratory pressures, tidal volume and respiratory rate into a single value. It allows physicians to evaluate adjustments made to mechanical ventilation by calculating a single value. High mechanical power value is associated with a high incidence of postoperative pulmonary complications and mortality . In short, the energy distributed to the respiratory system consists of the static composite (PEEP), the dynamic composite (driving pressure and tidal volume) and the resistive composite (the pressure required for gas flow). Because energy is equal to the pressure that causes a change in volume. The equation is as follows: MP= 0.098 × respiratory rate × tidal volume × (PEEP + ½(plateau-peep)+ (peak-plateau)). These parameters are monitored on the monitor while the patient is mechanically ventilated and placed into the equation. After general anesthesia, some postoperative pulmonary complications may be encountered. Exposure to high mechanical force in ventilated patients during surgery has been found to be associated with an increase in postoperative pulmonary complications and acute respiratory failure. This increases the length of hospital stay and mortality. In order to prevent ventilator-related lung damage, the mechanical ventilator must be adjusted to transfer the least amount of energy per unit time to the respiratory system for each patient. Early recognition of postoperative pulmonary complications that are likely to occur after surgery is important for rapid initiation of treatment. Incentive spirometry (triflo) can be used to make a rapid assessment of the respiratory capacity of patients. An incentive spirometer is a device that measures the volume of air drawn into the lungs during inspiration. As you breathe through an incentive spirometer, a piston inside the device rises and measures the volume of inhaled air. 1 ball is considered as 600ml, 2 balls as 900ml, and 3 balls as 1200ml flow.\]

Registry
clinicaltrials.gov
Start Date
July 1, 2025
End Date
April 15, 2026
Last Updated
9 months ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Gamze Talih

Principal Investigator

TC Erciyes University

Eligibility Criteria

Inclusion Criteria

  • Patients who will undergo elective percutaneous nephrolithotomy and agree to participate in the study.
  • ASA 1-3 patient

Exclusion Criteria

  • Patients with acute and chronic hypoxemia (PaO2\<65mmHg, SpO2\<95 in room air)
  • Patients with BMI\>35
  • Patients with obstructive sleep apnea syndrome
  • Patients with ASA 4 and above
  • Pregnant patients
  • Pneumonia, COPD attack etc. before the operation. people with lung disease
  • Unstable patients such as uncontrolled hypertension, decompensated heart
  • Mentally retarded and uncooperative patients

Outcomes

Primary Outcomes

mechanical power

Time Frame: 2 year

mechanical power=0.098\*minute ventilation \*(Ppeak-0.5\*(Pplato-PEEP)

Study Sites (1)

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