The Effect of Periodontal Treatment on Stress and Pregnancy Relationship

Not Applicable

Completed

• Conditions: Pregnancy Gingivitis

• Registration Number: NCT04315532
• Lead Sponsor: Tokat Gaziosmanpasa University

Brief Summary

There is a relationship between stress and pregnancy gingivitis. This relationship may be double-sided.

Detailed Description

The aim of this clinical study was to determine the effect of non-surgical mechanical periodontal treatment on sex steroid and stress markers at pregnancy gingivitis. A total of 84 subjects; 22 pregnant women with gingivitis (group 1) and 25 pregnant women with periodontal healthy (pregnant group), group 2), 22 non-pregnant women with gingivitis (group 3) and 15 non-pregnant women with periodontal healthy (non-pregnant group), group 4) participated in this study. Clinically, plaque index, gingival index, and probing pocket depth were measured at baseline and after therapy.

Study Timeline

• Study Start: 2016-04
• Primary Completion: 2016-10
• Study Completion: 2016-11
• Status Verified: 2020-03
• Study First Submitted: 2020-03-18
• Study First Submitted QC: 2020-03-18
• Study First Posted: 2020-03-19
• Last Update Submitted: 2020-03-19
• Last Update Posted: 2020-03-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 84

Inclusion Criteria

• being between the ages of 24-50
• being pregnant for 23-30 weeks (for pregnant individuals)
• not smoking.

Exclusion Criteria

• using antimicrobial or anti-inflammatory therapy within the previous 3 months,
• having systemic disease,
• having periodontitis,
• having deep caries lesions, and remnant roots and
• having lactation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Dehydroepiandrosterone (DHEA)	Baseline and after 8 weeks	The changes in DHEA levels within 8 weeks. Higher values represent a worse outcome. The decrease in DHEA levels is expected after periodontal treatment.
estrogen	Baseline and after 8 weeks	The changes in estrogen levels within 8 weeks. Higher values represent a worse outcome. The decrease in estrogen levels is expected after periodontal treatment.

Secondary Outcome Measures

Name	Time	Method
Gingival index	Baseline and after 8 weeks	The changes in gingival index level after periodontal treatment. Gingival index was measured for determining the severity of disease and clinical outcome. Higher values represent a worse outcome. After periodontal treatment, a reduction in gingival index value is expected.