Study of Betatrophin Levels in Patients With Type 2 Diabetes and Gestational Diabetes and Healthy Subjects
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 主要终点
- Serum levels of betatrophin in type 2 diabetes patients, gestational diabetes patients and pregnant women
研究概览
简要总结
Betatrophin is a newly identified hormone that promotes pancreatic beta cell proliferation, improves glucose tolerance and regulates lipids metabolism. A recent study showed that circulating concentrations of betatrophin doubled in type 1 diabetes. The objective of this study is to investigate the association of serum betatrophin levels with the progression of diabetic retinopathy in patients with type 2 diabetes and the level of betatrophin in gestational diabetes patients and pregnant women.
详细描述
200 subjects were recruited in this study and divided into six groups for comparison of the serum betatrophin. 70 healthy subjects and 20 healthy young volunteers were enrolled for investigating the role of betatrophin in energy homeostasis and the circadian rhythm. 50 patients with type 2 diabetes were classified into three groups by the stage of diabetic retinopathy. Rank test was used to analyze the correlation between the progression of diabetic retinopathy and circulating betatrophin. Betatrophin were measured by a commercially available enzyme-linked immunosorbent assay and confirmed via Western Blot.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetes mellitus patients
- •Patients with HbA1c >or= 7.0%
排除标准
- •Participation in other investigational Clinical Trial
- •Type 1 diabetes mellitus patients
- •Patients with history of severe hepatic dysfunction
- •Treatment with antifungal agent especially Miconazole
- •Patients with active smoking or history of smoking cessation less than 2 months
结局指标
主要结局
Serum levels of betatrophin in type 2 diabetes patients, gestational diabetes patients and pregnant women
时间窗: Up to one month
次要结局
- Correlation of betatrophin concentration with other variables(Up to one month)
研究者
Jing Dong
associate professor
Qingdao University