NCT00311974已完成4 期
The Effect of Dihydralazine on Renal Tubular Function and Vasoactive Hormones in Healthy Individuals
Regional Hospital Holstebro2 个研究点 分布在 1 个国家目标入组 16 人开始时间: 2006年4月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Fractional sodium excretion
研究概览
简要总结
We, the investigators at Holstebro Hospital, want to test the hypothesis that dihydralazine leads to the activation of the sympathetic nervous system in healthy individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Ages 18 to 40 years.
- •Body mass index less than or equal to 30 kg/m2
排除标准
- •History or clinical signs of heart, lung, kidney, or endocrine organ disease.
- •Abnormal biochemical screening of the blood regarding: B-hemoglobin, P-sodium, P-potassium, P-creatinine, P-albumin, P-bilirubin, P-alanine aminotransferase, P-alkaline phosphatase, P-cholesterol, and B-glucose.
- •Abnormal screening of the urine regarding: albumin and glucose
- •Malignant disease.
- •Known arterial hypertension or measured 24 hour blood pressure above 135 mmHg systolic or 85 mmHg diastolic.
- •Alcohol abuse.
- •Drug use or abuse.
- •Known intolerance or allergy to dihydralazine
- •Blood donation within 1 month of the start of the study.
结局指标
主要结局
Fractional sodium excretion
Heart rate
Blood pressure
次要结局
未报告次要终点
研究者
研究点 (2)
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