The Utility of stress Hyperglycemia Ration (SHR) and Serum Cortisol in Prediction of delayed Ischemic Neurologic Deficit (DIND) in patients with aneurysmal subarachnoid hemorrhage: A Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- To study the association between stress hyperglycaemia ratio (SHR) and occurrence of delayed ischemic neurologic deficit (DIND) in patients with aSAH.
研究概览
简要总结
Aneurysmal subarachnoid hemorrhage (aSAH), characterized by bleeding in the subarachnoid space due to aneurysm rupture, and remains a critical neurosurgical challenge. Its devastating impact stems not only from the initial hemorrhage but also from delayed complications like vasospasm leading to worsening outcomes. Early identification of DIND is crucial for guiding preventative and therapeutic interventions.
The quest for non-invasive predictors of DIND has led to exploring readily available biomarkers, like stress hyperglycemia ratio (SHR) and serum cortisol. The intricate interplay between stress, hyperglycemia, and vasospasm in aSAH is well-documented in scientific literature. This study aims to assess the utility of SHR and serum cortisol levels in predicting delayed ischemic neurologic deficit (DIND) in patients with aSAH
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Confirmed diagnosis of aSAH based on CT.
排除标准
- •Known adrenal disorders.
- •Established vasospasm in the initial CT imaging.
- •Patient on steroids.
结局指标
主要结局
To study the association between stress hyperglycaemia ratio (SHR) and occurrence of delayed ischemic neurologic deficit (DIND) in patients with aSAH.
时间窗: Baseline,discharge ,2 weeks
次要结局
- To study the relationship between SHR & serum cortisol levels in patients with aSAH(baseline)
研究者
Dr Shweta Suresh Naik
National Institute of Mental Health and Neurosciences