Effect of Supplementation With Pumpkin Seed Oil Versus Pumpkin Seeds on Blood Pressure and Menopausal Symptoms in Non-hypertensive Postmenopausal Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- Change in systolic and diastolic blood pressure
研究概览
简要总结
The purpose of this randomized control trial is to compare the effect of pumpkin seed oil 2g/day with pumpkin seeds given as a dose of 1½ teaspoons/ 4.1 grams a day to provide 2g of lipid (equivalent to 2 grams of oil) on BP (systolic and diastolic), endothelial function, serum lipids, C-reactive protein (CRP) concentrations, and menopausal symptoms in postmenopausal women.
详细描述
At the onset of menopause CVD rates increase in women. A beneficial effect of pumpkin seed oil on blood pressure has been observed in postmenopausal women. More than 1 in 3 female adults have some form of cardiovascular disease (CVD), which is affected by blood pressure.
Pumpkin seed is a good source of phytoestrogens. Phytoestrogens are compounds found in plants and are comparable to human estrogen, capable of producing estrogenic effects. Studies in post menopausal women have demonstrated that pumpkin seed oil, at a dose of 2g per day for 12 weeks can decrease blood pressure and reduce menopausal symptoms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Non-hypertensive with blood pressure less than140/90 mmHg
- •Post menopausal women or had a bilateral oophorectomy
排除标准
- •Hypotensive women with BP <90/60
- •Taking medications to manage blood pressure and blood lipids
- •Taking estrogen supplements or on hormone replacement therapy
- •Taking pumpkin seed oil supplements
- •Consuming pumpkin seeds more than ¼ cup a month
- •Diagnosed with depression and taking antidepressants
研究组 & 干预措施
Pumpkin seed oil
Pumpkin seed oil (1g) capsules - 2 capsules per day for 12 weeks
干预措施: Pumpkin seed oil (Dietary Supplement)
Pumpkin seeds
Packet of pumpkin seeds (4.1 grams /~0.15ounces) - 1 pack per day for 12 weeks
干预措施: Pumpkin seeds (Dietary Supplement)
结局指标
主要结局
Change in systolic and diastolic blood pressure
时间窗: change measured - baseline and 12 weeks
次要结局
- Change in Total Cholesterol level (mg/dl)(change measured - baseline and 12 weeks)
- Change in Plasma Triglycerides (mg/dl)(change measured - baseline and 12 weeks)
- Change in Plasma High-Density Lipoprotein Cholesterol (mg/dl)(change measured - baseline and 12 weeks)
- Change in Plasma Low-Density Lipoprotein Cholesterol (mg/dl)(change measured - baseline and 12 weeks)
- Change in C-reactive protein (CRP)(change measured - baseline and 12 weeks)
- Change in Endothelial Function(change measured - baseline and 12 weeks)