Procalcitonin-Guided Antibiotic Therapy in Bronchiectasis
Not Applicable
Completed
- Conditions
- ProcalcitoninBronchiectasisAntibiotic Therapy
- Registration Number
- NCT03058718
- Lead Sponsor
- Qilu Hospital of Shandong University
- Brief Summary
To explore effectiveness of procalcitonin-guided antibiotic therapy in acute exacerbations of bronchiectasis, and to explore the clinical value of procalcitonin in bronchiectasis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 210
Inclusion Criteria
- Bronchiectasis was diagnosed by high-resolution computed tomography based on the criteria published by McShane PJ et al.
- Acute exacerbations of bronchiectasis.
- Aged >= 18 years.
- Procalcitonin been detected after admission.
Exclusion Criteria
- Associated with chronic obstructive pulmonary disease.
- Associated with asthma.
- Traction bronchiectasis caused by pulmonary fibrosis.
- Rule out other possible cause procalcitonin increased diseases such as cancer, connective tissue disease, active tuberculosis, chronic liver disease and respiratory system than the bacterial infection.
- Clinical data were incomplete.
- Can not follow up with the person.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Antimicrobial prescription rate 14 days Number of days of antimicrobial application 14 days The number of days in hospital 14 days
- Secondary Outcome Measures
Name Time Method mortality rate 14 days fungal infection rate 14 days Effective rate of clinical treatment 14 days Quality of life score 6 months Adverse reaction rate 14 days Bacterial resistance rate 14 days The incidence of complications 14 days The proportion of patients with at least once acute exacerbation in 6 months 6 months