Holter monitoring to assess QT interval and heart rate variability in women diagnosed previously with broken heart syndrome

Not Applicable

Completed

• Conditions: Takotsubo Syndrome; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12618001812280
• Lead Sponsor: Dr Paul Bridgman

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-11-07
• Study Completion: 2019-02-18
• Last Update Posted: 11 November 2019

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 24

Inclusion Criteria

Twenty four women with a past history of admission to hospital with either takotsubo syndrome or a non –ST elevation acute coronary syndrome (NSTEACS). There will be twelve in each group.

Takotsubo syndrome will be defined according to modified-Mayo criteria. That is a hospital presentation with a troponin elevation, a recognised regional wall motion pattern that fully resolves and absence of culprit coronary artery disease on coronary angiography.

Non-ST elevation acute coronary syndrome is defined as a hospital presentation with either unstable angina or non-ST elevation myocardial infarction.

Exclusion Criteria

Impaired left ventricular function (LVEF <50%)
Current therapy with beta blockade
History of panic disorder
Atrial fibrillation
Left bundle branch block

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute QT interval changes with breathing exercises measured by continuous Holter monitoring[During 3-minute intervention]

Secondary Outcome Measures

Name	Time	Method
QT interval change during usual activity measured by continuous Holter monitoring[The 24 hour period after the intervention];Heart rate variability during usual activities measured by continuous Holter monitoring[The 24 hour period after the intervention]