Immunological Response After Shrimp Oral Immunotherapy Treatment

Not Applicable

Completed

• Conditions: Immunotherapy; Allergy to Shrimp
• Interventions: Other: shrimp allergy with intend to eat shrimp

• Registration Number: NCT04552522
• Lead Sponsor: Mahidol University

Brief Summary

Oral immunotherapy is effective in desensitized food allergy. Shrimp allergy is increasing in Thailand. So the purpose of our study is to determine level of specific immunoglobulin E antibodies to shrimp, Immunoglobulin G4 and immunoblot analysis in shrimp allergy patients after shrimp oral immunotherapy.

Detailed Description

All subject in this study were sensitized to shrimp. All patient was clinically evaluated, with focus on shrimp allergy by medical history, medical examination and gold standard oral food challenge test. Compare oral immunotherapy to shrimp and shrimp avoidance. Blood sample was taken for baseline determination of immunoglobulin E antibodies to shrimp. The primary outcome was the specific immunoglobulin E antibodies to shrimp,Immunoglobulin G4 and immunoblot analysis in case that oral immunotherapy.

Study Timeline

• Study Start: 2020-08-28
• Study First Submitted: 2020-09-13
• Study First Submitted QC: 2020-09-13
• Study First Posted: 2020-09-17
• Primary Completion: 2024-10-31
• Study Completion: 2024-12-30
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-21
• Last Update Posted: 2025-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Age 12 - 40 years old
• History of Immunoglobulin E-mediated shrimp allergy > 3 episode/year or disturb quality of life
• Positive oral food challenge test for shrimp

Exclusion Criteria

• History of shrimp anaphylaxis (include cardiovascular or neurological symptoms)
• Shellfish dependent exercise induced anaphylaxis
• History of cardiovascular disease, uncontrolled asthma, severe atopic dermatitis
• History of Beta-blocker, Angiotensin-converting enzyme inhibitor, Angiotensin receptor blocker, Calcium channel blocker

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Shrimp allergy with Intend to eat shrimp	shrimp allergy with intend to eat shrimp	Case shrimp Immunoglobulin E mediated allergy and intend to eat shrimp and start oral immunotherapy for shrimp

Primary Outcome Measures

Name	Time	Method
specific Immunoglobulin E, Immunoglobulin G4, immunoblot analysis from Desensitized to shrimp allergen	1 year	To follow-up the level of specific Immunoglobulin E, Immunoglobulin G4, immunoblot analysis from Desensitized to shrimp allergen

Secondary Outcome Measures

Name	Time	Method
Adverse event from Shrimp oral immunotherapy	1 year	To follow up adverse event from Shrimp oral immunotherapy

Trial Locations

Locations (1)

Siriraj Hospital; 🇹🇭 Bangkoknoi, Bangkok, Thailand