Immunological Response After Shrimp Oral Immunotherapy Treatment
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Mahidol University
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Change in Eliciting Dose of Shrimp During Oral Food Challenge
Study Overview
Brief Summary
Oral immunotherapy is effective in desensitized food allergy. Shrimp allergy is increasing in Thailand. So the purpose of our study is to determine level of specific immunoglobulin E antibodies to shrimp, Immunoglobulin G4 and immunoblot analysis in shrimp allergy patients after shrimp oral immunotherapy.
Detailed Description
All subject in this study were sensitized to shrimp. All patient was clinically evaluated, with focus on shrimp allergy by medical history, medical examination and gold standard oral food challenge test. Compare oral immunotherapy to shrimp and shrimp avoidance. Blood sample was taken for baseline determination of immunoglobulin E antibodies to shrimp. The primary outcome was the specific immunoglobulin E antibodies to shrimp,Immunoglobulin G4 and immunoblot analysis in case that oral immunotherapy.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 12 Years to 40 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age 12 - 40 years old
- •History of Immunoglobulin E-mediated shrimp allergy > 3 episode/year or disturb quality of life
- •Positive oral food challenge test for shrimp
Exclusion Criteria
- •History of shrimp anaphylaxis (include cardiovascular or neurological symptoms)
- •Shellfish dependent exercise induced anaphylaxis
- •History of cardiovascular disease, uncontrolled asthma, severe atopic dermatitis
- •History of Beta-blocker, Angiotensin-converting enzyme inhibitor, Angiotensin receptor blocker, Calcium channel blocker
Arms & Interventions
Shrimp allergy with Intend to eat shrimp
Case shrimp Immunoglobulin E mediated allergy and intend to eat shrimp and start oral immunotherapy for shrimp
Intervention: shrimp allergy with intend to eat shrimp (Other)
Shrimp allergy with avoid shrimp
Case shrimp allergy with avoid shrimp
Outcomes
Primary Outcomes
Change in Eliciting Dose of Shrimp During Oral Food Challenge
Time Frame: Baseline and 12 months
Change in the eliciting dose (ED) of shrimp protein during oral food challenge from baseline to 12 months in participants with shrimp allergy undergoing shrimp oral immunotherapy compared with avoidance.
specific Immunoglobulin E, Immunoglobulin G4, immunoblot analysis from Desensitized to shrimp allergen
Time Frame: 1 year
To follow-up the level of specific Immunoglobulin E, Immunoglobulin G4, immunoblot analysis from Desensitized to shrimp allergen
Secondary Outcomes
- Adverse Event From Shrimp Oral Immunotherapy(1 year)
- Adverse event from Shrimp oral immunotherapy(1 year)