Effects of Chromium Picolinate on Food Intake, Satiety, and Eating Attitudes in Overweight Women With Food Cravings
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Food intake at both a test lunch meal and at a test dinner meal presented 4.5 hours later
研究概览
简要总结
The purpose of this study is to test the effects of chromium picolinate on food intake, food cravings, eating attitudes, and appetite. If chromium picolinate is found to have a beneficial impact on satiety and food intake, then this supplement may be an alternative or adjunctive treatment for overweight people desiring to modify their food intake. The primary hypothesis of this study is that among individuals who report being carbohydrate cravers, chromium picolinate supplementation will reduce food intake during a test lunch meal and produce greater satiety in comparison to a placebo.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Inclusion criteria are:
- •Healthy female who has not been diagnosed with diabetes, cardiovascular illness, or other chronic diseases,
- •Food craver, determined by self-reported craving for carbohydrates on two out of three validated measures of food cravings,
- •> 18 years of age and < 50 years of age, and
- •Body mass index between 25 and 39.9 kg/m
- •Participants will be scheduled for testing during the luteal phase of their menstrual cycle to limit the confounding effect of the menstrual cycle on energy intake. We will include women who are taking monophasic oral contraceptives but will exclude other oral contraceptive regimens. Participants with very irregular menstrual cycles will also be excluded because this irregularity will make it very difficult to schedule testing during the luteal phase of the menstrual cycle.
排除标准
- •Potential participants will be excluded for the following reasons:
- •Participants who report smoking cigarettes will be excluded because of the effects of nicotine upon taste and appetite,
- •Participants who have a diagnosable eating disorder (i.e., anorexia or bulimia nervosa) will also be excluded since intentional restriction of eating and binge eating/overeating could increase the variability of the data,
- •Participants who report using diet pills will be excluded since diet pills may potentially influence appetite, hunger, and/or satiety,
- •Participants will be excluded if they are taking anti-depressant medications, anti-psychotic medications, or any medications that may potentially influence appetite, hunger, and/or satiety,
- •Participants who are not determined to be carbohydrate cravers will be excluded,
- •Participants will also be excluded if they report any allergies to the foods that will be used in the study.
研究组 & 干预措施
Visual Analogue Scale Ratings
Food intake data and its coefficients, including total food intake, food not eaten, duration of the meal, and bite rate. A mixed model analysis of variance will also be conducted on ratings of food cravings and eating atttudes. Changes in hunger and satiety ratings between, before, and after the meals will be compared for difference across treatment conditions.
干预措施: Chromium Picolinate (Drug)
Consuming less Lunch allows consumption of more dinner
Test whether chromium picolinate supplementation affects food cravings, eating attitudes, and satiety in healthy, overweight and/or obese, adult women who are determinded to be carbohydrate cravers. Whether participants who eat less at a lunch test meal consume more food at an ad lib dinner test meal with a diversity of foods.
干预措施: Chromium Picolinate (Drug)
结局指标
主要结局
Food intake at both a test lunch meal and at a test dinner meal presented 4.5 hours later
时间窗: 8 weeks
次要结局
- Hunger and satiety between the lunch and dinner meal(8 weeks)
研究者
William Cefalu, MD
Principal Investigator
Pennington Biomedical Research Center