Effect of hematopoietic growth factors therapy on brain injury
- Conditions
- Diseases of the circulatory system
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
In terms of subject selection criteria, the following conditions apply: 1) Adults aged 19 and above who are capable of providing voluntary consent, 2) Individuals with brain injuries occurring after the acute phase (one week after brain injury) such as ischemic brain injury, hypoxic-ischemic brain injury, hemorrhagic brain injury 3) Individuals who, according to the attending physician, are clinically eligible for re-enrollment in the study at least 6 months after the last hematopoietic growth factor injection.
The exclusion criteria for the subjects are as follows: 1) Individuals under the age of 19 who are incapable of providing voluntary consent, 2) Presence of cerebral lesions such as tumors or infections, 3) Use of anticoagulant warfarin (coumadin) (excluding medications from the antiplatelet drug class), 4) Leukopenia, thrombocytopenia, polycythemia, 5) History of malignant disease or myeloproliferative disorders, 6) Septic embolism, malignant hypertension, hyperkalemia, 7) Hepatic or renal dysfunction; serum creatinine > 3 mg/dl, 8) Allergy to erythropoietin or G-CSF medications, 9) Exclusion criteria for MRI examination, 10) Pregnant or breastfeeding women, 11) Body temperature above 38 degrees Celsius, presence of pneumonia on chest radiography, 12) Recurrent pneumonia symptoms, 13) Blood pressure exceeding 140/90 mmHg despite the use of antihypertensive medications, 14) Hemoglobin levels exceeding 15 g/dL. Individuals meeting any of these criteria will be excluded from the target group.
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Systolic Blood Pressure;Diastolic Blood Pressure;Pulse Rate;Complete Blood Test;Erythropoietin;CD34+
- Secondary Outcome Measures
Name Time Method Manual Muscle Testing;Rang of Motion;Modified Ashworth Scale;Modified Barthel index;Functional independence measure;Grip and Pinch Power;Box and Block Test;Jebsen Taylor Hand Function Test