Studies of Infertility in Patients With Chronic Kidney Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infertility
- Sponsor
- Lund University
- Locations
- 2
- Primary Endpoint
- concentration of sex hormone levels in plasma
- Status
- Withdrawn
- Last Updated
- 7 years ago
Overview
Brief Summary
Patients with chronic kidney disease (both men and women), especially those with terminal renal failure, manifest infertility. There has been demonstrated several hormonal changes in patients on dialysis. Increased levels of luteinizing hormone (LH) has been seen in men (12). In women the opposite has been reported. The number of spermatocytes is reduced and a disturbance in maturation has been observed.
This project is aimed to study the influence of uremic milieu on fertility in men and women. The hypopituitary/hypothalamus gland axis and hormonal levels will be studied.
Detailed Description
Renal elimination of hormones and peptides. By using a human transplantation model the investigators will study changes in hormonal levels before and after a successful transplantation up to 12 months. Hormones: testosterone, SHBG (sex hormone binding globulin), LH (luteinizing hormone), FSH (follicle stimulating hormone), estradiol and inhibin B. Analysis of sperm quality, concentration, motility, morphology and as well DNA-fragmentation index (DFI) in men with chronic kidney disease. In women the investigators will study the maturation of follicles via vaginal ultrasound. Controls are persons from a study at Dept of Reproductive Medicine.
Investigators
Eligibility Criteria
Inclusion Criteria
- •GFR-levels
Exclusion Criteria
- •\> 50 years old
Outcomes
Primary Outcomes
concentration of sex hormone levels in plasma
Time Frame: up to three years
Secondary Outcomes
- sperm motility(up to three years)