Can acupuncture affect cytokine levels in multiple sclerosis?
Not Applicable
- Conditions
- Multiple sclerosisNervous System Diseases
- Registration Number
- ISRCTN34352011
- Lead Sponsor
- Scleroseforeningen
- Brief Summary
2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34265224/ (added 16/07/2021)
- Detailed Description
Not available
Recruitment & Eligibility
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
1. Aged 18 years or older
2. Diagnosed with relapsing-remitting multiple sclerosis for a minimum of 2 years
3. Must be able to walk unassisted (equivalent to an EDSS of 6.5)
4. Must have been relapse-free for the past 3 months
5. If treated with disease-modifying medicine, treatment must have been unchanged for the past 3 months
Exclusion Criteria
1. Significant co-morbidities (heart disease, diabetes, Mb. Crohn or other) which may affect the immune system
2. Has received acupuncture treatment within the past 3 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cytokine plasma levels (IFN?, IL-1ß, IL-6, IL-8, IL-12p70, IL-13, TNFa, IL-10, IL-4, IL-2 and IL-17A) measured using the Mesoscale Multi-spot Assay System on blood samples taken at baseline, the day after the 4th treatment, the day after the final treatment, and at 4 weeks following the final treatment
- Secondary Outcome Measures
Name Time Method Health-related quality of life (HRQoL) measured using the MS-specific Functional Assessment of Multiple Sclerosis (FAMS) instrument at baseline, after 4 weeks (following the last treatment), and at 4 weeks after the final treatment