Multicentric trial on role of urinary biomarkers in predicting renal injury in high risk term neonates - one year follow up

International society of Nephrology0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•All high risk neonates >36 weeks of gestation age are included.
•High risk neonates include:
•1. Those with severe sepsis (any 2 organ dysfunction) or septic shock requiring mechanical ventilation or inotropic support or coagulopathy with bleeding manifestations.
•2. Those with Hypoxic Ischemic Encephalopathy stage 2 or 3 (Sarnath classification).
•3. Any neonate requiring major surgical intervention
•4. Hemodynamically significant congenital heart disease requiring mechanical ventilation or ionotropic support.
•5. Neonates requiring nephrotoxic medications â?? aminoglycosides, NSAIDS for >7 days.
•6. Neonates with severe IUGR (birth weight < 3 rd centile using Fenton chart) or with Doppler abnormalities.
•7. Neonates with hyperbilirubinemia requiring exchange transfusion
•8. Neonates with severe dehydration ( >10% weight loss) with hypernatremia ( >145) with clinical features of dehydration with decreased urine output.
•9. Neonates with PPHN/MAS on mechanical ventilation

•Neonates with major renal anomalies like Posterior Urethral Valve and any anomalies affecting both kidneys.
•Parents who refuse to consent.

发起方

International society of Nephrology