Lung Ultrasound Score in Covid 19 Infectious Disease in Critical Care (LUS-COVID19)

Completed

• Conditions: COVID
• Interventions: Procedure: lung ultrasound (LUS)

• Registration Number: NCT04393402
• Lead Sponsor: Centre Hospitalier Universitaire de Nice

Brief Summary

It might be necessary with Sars-Cov2 pneumopathy patient to repeat thoracic images, the tomodensitometry ones in particular. This task is difficult and nearly impossible for several reasons: respiratory and hemodynamic unstable patient, prone position and due to the high contagious nature of the disease.

The lung ultrasound is an easy tool, fast (between 5 and 10 minutes) and as a limited training.

In the context of the Sars-Cov2 epidemic, Buonsenso and al case report depict the first lung ultrasound for a Covid 19 patient.

Peng and al in Intensive Care Medicine accentuate the usefulness of this particular technic.

In the American Journal of Respiratory and Critical Care Medicine, a study has been published as a point-of-care, in which the doctors reported using the lung ultrasound with intensive and critical care patient.

In Critical Care 2016, it has been showed that ultrasound allowed with neat precisions, to predict severe ARDS patient response to the prone position, all-cause.

Another researchers team found a good correlation between lung ultrasound, the SOFA, APACHE II, CPIS score, and patient mortality.

And a new applicability in the pulmonary recruitment by PEEP titration has been presented.

The aim of this study is to evaluate the lung ultrasound in Covid19 ARDS.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-20
• Study First Submitted: 2020-05-15
• Study First Submitted QC: 2020-05-18
• Study First Posted: 2020-05-19
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-09
• Last Update Posted: 2025-04-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Diagnosed Sars-Cov2 patient, with PCR method qualitative or quantitative as usual.
• Intensive or critical care admission
• ARDS with PaO2/FiO2 <300 at the admission
• Ventilatory support or oxygen-therapy

Exclusion Criteria

• Age < 18 years-old
• Pregnancy
• Patient with tutor- or curatorship or in prison

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with Covid-19 and admitted in critical care unit	lung ultrasound (LUS)	-

Primary Outcome Measures

Name	Time	Method
LUS applicability with COVID 19	10 months	In dorsal position, or in prone position, the two hemithorax will be subdivided in 6 parts, and a score will be attributed with the following criteria : A-Lines (0 point), \> 3 B-lines (1 point), B-Lines coalscent (2 points), and pulmonary consolidation (3 points). For the echography we can use a convexe sonde, or a "cardiac" sonde.

Secondary Outcome Measures

Name	Time	Method
Radiographic correlation (chest Xray and tomodensitometry)	10 months	Comparison between Xray / CT scan exam and LUS
LUS Mortality prediction	10 months	according to LUS score, ventilatory mode and parameters, medical history and bood analysis results
Prediction of Prone position response	10 months	comparison of LUS score depending of the position used for performing LUS

Trial Locations

Locations (1)

CHU de Nice; 🇫🇷 Nice, France