The adaptive immunity and the incidence of SARS-CoV-2 infection in employees with occupational risk of infection taking into account physical fitness
- Conditions
- U07.1COVID-19, virus identified
- Registration Number
- DRKS00034779
- Lead Sponsor
- Betriebsärztlicher Dienst Universitätsklinikum Bonn
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 1000
Inclusion Criteria
Employees are recruited who are exposed to a high risk of infection with relevant SARS-CoV-2 variants due to their professional activities in facilities and have been immunized.
Exclusion Criteria
Non aplicable.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method a. Humoral and cellular immunity:<br>n=30: SARS-CoV-2-S1-specific B and T memory cells 1. <br>n=300-1000 plaque reduction neutralization test<br>2. anti-spike IgG-AK 2. anti-nucleocapsid IgG-AK<br>3. saliva anti-spike IgG-AK
- Secondary Outcome Measures
Name Time Method b. Incidence of SARS-CoV-2 infections using qualitative questionnaires Uniklinik Bonn<br>c. Qualitative determination of the physical activity of the test subjects using a questionnaire -Freiburg Questionnaire on Physical Activity<br>d. Quantitative determination of physical activity using bicycle ergometry: power output, heart rate, blood pressure