Genetic Analysis of Children With Cyclic Vomiting Syndrome and Migraines
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 586
- 试验地点
- 1
- 主要终点
- Identify novel genes that contribute to the risk of CVS using genomewide association analysis approach.
研究概览
简要总结
The purpose of this study is to determine if there are genetic variations that can explain a genetic basis for cyclic vomiting syndrome (CVS).
详细描述
The purpose of this study is to determine if there are genetic variations that can explain a genetic basis for cyclic vomiting syndrome (CVS), various phenotypes of CVS (e.g. menstrual, Sato, calendar-tied) and migraine headaches (e.g. with aura, without aura, hemiplegic migraine). This information will allow physicians to improve care for patients who have been diagnosed with this disease and to provide their parents with more complete information regarding the cause of this disease. This research is being done because many unanswered questions remain regarding children with CVS.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects age 0-21 years old with CVS (different phenotypes). Each patient's authorized legal guardian must understand the nature of the study and must provide written informed consent.
排除标准
- •Subjects age > 22 years old Vomiting is not due to CVS or other related condition
结局指标
主要结局
Identify novel genes that contribute to the risk of CVS using genomewide association analysis approach.
时间窗: 3 years
次要结局
- Perform genotype-phenotype correlations between genetic profiles and various phenotypes of CVS (e.g. menstrual, Sato, calendar-tied) and migraine headaches (e.g. with aura, without aura, hemiplegic migraine)(3 years)
研究者
Katja Kovacic
Professor of Gastroenterology, M.D.
Medical College of Wisconsin