Genetic an Functional Studies of Patient With Inflammatory Bowel Disease

Completed

• Conditions: Inflammatory Bowel Diseases

• Registration Number: NCT03751722
• Lead Sponsor: University Hospital, Lille

Brief Summary

The objective of this study is to study the response of macrophages, isolated from patients with ulcerative colitis (Crohn's disease) or Crohn's disease (CD), to 6 candidate enterogenous and their derivatives, depending on the genotype for associated polymorphisms. to the development of IBD

Detailed Description

Not available

Study Timeline

• Study Start: 2007-02
• Primary Completion: 2017-04-10
• Study Completion: 2017-04-10
• Status Verified: 2018-11
• Study First Submitted: 2018-11-20
• Study First Submitted QC: 2018-11-21
• Last Update Submitted: 2018-11-21
• Study First Posted: 2018-11-23
• Last Update Posted: 2018-11-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 630

Inclusion Criteria

• patient with definite crohn's disease or ulcerative colitis

Exclusion Criteria

• patient receiving anti-TNF therapy during 14 days before inclusion.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Isolated macrophage response measured by PCR	Baseline: one session	identification of macrophage activation markers specific analysis of gene expression (by PCR in real time) and / or the production (ELISA) of proinflammatory molecules (IL-6, TNF-1 and IL-8), anti-inflammatory (IL-10) and immunomodulatory (IL4,PPAR -2, MOR)

Trial Locations

Locations (1)

CHRU, Hôpital Claude Huriez; 🇫🇷 Lille, France