NCT03751722已完成不适用
Genetic an Functional Studies of Patient With Inflammatory Bowel Disease
University Hospital, Lille1 个研究点 分布在 1 个国家目标入组 630 人开始时间: 2007年2月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 630
- 试验地点
- 1
- 主要终点
- Isolated macrophage response measured by PCR
研究概览
简要总结
The objective of this study is to study the response of macrophages, isolated from patients with ulcerative colitis (Crohn's disease) or Crohn's disease (CD), to 6 candidate enterogenous and their derivatives, depending on the genotype for associated polymorphisms. to the development of IBD
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient with definite crohn's disease or ulcerative colitis
排除标准
- •patient receiving anti-TNF therapy during 14 days before inclusion.
结局指标
主要结局
Isolated macrophage response measured by PCR
时间窗: Baseline: one session
identification of macrophage activation markers specific analysis of gene expression (by PCR in real time) and / or the production (ELISA) of proinflammatory molecules (IL-6, TNF-1 and IL-8), anti-inflammatory (IL-10) and immunomodulatory (IL4,PPAR -2, MOR)
次要结局
未报告次要终点
研究者
研究点 (1)
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