the effect of improving negative symptoms with B12 and folic acid in patients with chronic mental illness

Phase 3

• Conditions: negative symptoms.; Schizophrenia; 0-1-2-3-5-

• Registration Number: IRCT20221018056233N1
• Lead Sponsor: niversity of social welfare and rehabilitation sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 February 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

18 to 60 years old who have been treated with antipsychotic drugs for at least 6 months
No history of taking vitamins B12 and folic acid in the last 1 month
Absence of liver disorders, megaloblastic anemia and special diet , use of other nutritional supplements During the last 1 month
Not consuming alcohol and other substances in the last 6 months
Absence of pregnancy and breastfeeding
negative symptoms

Exclusion Criteria

history of taking vitamins B12 and folic acid in the last 1 month
liver disorders, megaloblastic anemia and special diet , use of other nutritional supplements During the last 1 month
alcohol and other substances in the last 6 months
pregnancy and breastfeeding

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
B12-acid folic-negative symptoms. Timepoint: At the beginning of the study and two months after taking B12 and folic acid, the blood level of vitamins will be measured and the SANS questionnaire will be filled. Method of measurement: SCALE FOR THE ASSESSMENT OF NEGATIVE SYMPTOMS/ Blood level of b12 and acid folic.