ow dose aspirin therapy before or after 12 weeks gestation for preventing preeclampsia A randomized controlled trial

AIIMS BHUBANESWAR0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•women attending antenatal clinic in whom pregnancy has been diagnosed by ultrasonography that is only after appearance of cardiac activity, before 12 weeks of gestational age measured by crown rump length having either one major risk factor or more than one minor risk factor.
•major risk factors:
•1) history of preeclampsia in previous pregnancy
•2) chronic hypertension
•3) type 1 or 2 diabetes
•4) auto immune diseases like SLE antiphospholipid antibody syndrome etc
•5) diagnosed renal disease
•6) IVF conception
•7) multifetal gestation
•minor risk factors
•1) primiparity
•2) obesity with BMI more than 30 meter square per kg body weight
•3) age above 35 years
•4)pregnancy interval of more than 5 years

•if pregnant women coming to antenatal opd for the first time at or after 12 weeks of gestation, even with presence of risk factors patient will not be recruited in study.
•other risk factors:
•1) aspirin hyper sensitivity
•2) hypersensitivity to other salicylates
•3) nasal polyps
•4) bronchial asthma
•5) gastrointestinal bleeding
•6) peptic ulcer disease
•7) genitourinary tract bleed
•8) severe hepatic dysfunction
•9) severe renal dysfunction where NSAIDS are contraindicated
•10) if any anomaly detected in fetus in USG during recruitment
•11) if pregnant women are already on aspirin therapy before recruitment

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