Assessment of plasma dexamethasone level after 1-mg dexamethasone suppression test in adults with obesity
Phase 1
Completed
- Conditions
- compared the plasma dexamethasone levels after 1-mg DST in healthy obese participants and in normal-weight participants.Plasma dexamethasone, Dexamethasone levels, 1-mg dexamethasone suppression test, Obesity
- Registration Number
- TCTR20220223003
- Lead Sponsor
- Ratchadapisek Research Funds
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 92
Inclusion Criteria
participants aged more than 18 years
Exclusion Criteria
-pregnancy, diabetes mellitus, known CS, psychiatric disease, chronic liver disease, chronic renal failure stage 3 to 5, nephrotic syndrome, malabsorption disease
-Heavy alcohol drinking more than 30 gm/day
-taking drugs that interfering CYP3A4 within 1 month or oral contraceptives within 6 weeks prior to the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Compare plasma dexamethasone levels after 1-mg DST in obese participants and in normal-weight participants 12 mo LC-MS/MS
- Secondary Outcome Measures
Name Time Method Association of Sex, BMI, BSA and dexamethasone level 12 mo LC-MS/MS,proportion of participants achieving the plasma dexamethasone levels more than 3.3 nmol/L among the BMI groups 12 mo LC-MS/MS