Effects of Quercetin on plasma total antioxidant capacity, lipid peroxidation, blood pressure, inflammatory markers and disease activity in patients with Rheumatoid Arthritis
- Conditions
- Condition 1: Rheumatoid Arthritis. Condition 2: Rheumatoid arthritis.Seropositive rheumatoid arthritisOther rheumatoid arthritis
- Registration Number
- IRCT138807252394N2
- Lead Sponsor
- Iran Univesity of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Willing to participate in study, Clinical diagnosis of AR (meeting the American college of rheumatology 1987 criteria), Ages between 19 – 70 years , No smoking or addiction , No drug type and dose fluctuation since 1 month prior to the study and during intervention period , Not having severe cardiovascular, hepatic, kidney, gastrointestinal, thyroid, parathyroid diseases, diabetes and inflammation, Not using medications except for AR conventional drugs, Not using antioxidant supplements during last month, No pregnancy or lactation Exclusion criteria: Compliance less than 70%, Disinclination to continue for cooperation, developing illnesses which need particular cures or interfere with intervention such as increasing the disease activity or trauma
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Total antioxidant capacity (TAC). Timepoint: 8 weeks. Method of measurement: colorimetric assay.;Hs-TNF-alpha. Timepoint: 8 weeks. Method of measurement: ELISA.;Hs- CRP. Timepoint: 8 weeks. Method of measurement: ELISA.;Ox-LDL. Timepoint: 8 weeks. Method of measurement: ELISA.;Malondialdehyde. Timepoint: 8 weeks. Method of measurement: chemical colorimetric.;Disease activity score- 28 joints(DAS-28). Timepoint: 8 weeks. Method of measurement: Physical examination.;Morning stiffness. Timepoint: 8 weeks. Method of measurement: question.;Blood pressure. Timepoint: 8 weeks. Method of measurement: sphyngomanometer.
- Secondary Outcome Measures
Name Time Method Rheumatoid factor(RF). Timepoint: 8 weeks. Method of measurement: turbidometric assay.;Eritrocyte sedimentation rate(ESR). Timepoint: 8 weeks. Method of measurement: .