The Role of Copeptin Testing During Pre-hospital Care in the Treatment of Chest Pain Suggestive of Acute Coronary Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 320
- 试验地点
- 2
- 主要终点
- Blood copeptin concentration (pmol/l)
研究概览
简要总结
The main objective of our study is to evaluate the diagnostic value of copeptin testing in association with troponin HS testing during pre-hospital care (ambulance care) in the treatment of patients whose pattern of use is the occurrence chest pain suggestive of ACS but not ST+.
详细描述
The secondary objectives of this study are to:
A. Evaluate the diagnostic value of determination of copeptin testing in pre-hospital care in another diagnosis;
B. Assess the prognostic value of copeptin assay on vital prognosis at day 28;
C. Evaluate the kinetics of copeptin and troponin HS between initial ambulance care and arrival at the emergency department;
D. Evaluate the potential impact of copeptin testing on pre-hospital patient care;
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all major adult patients taken in charge by the emergency ambulance services of the participating centers for non-traumatic chest pain for suspected ACS and an electrocardiogram initially excluding an ST segment elevation
排除标准
- •The patient is participating in another study
- •The patient is in an exclusion period determined by a previous study
- •The patient is under judicial protection, under tutorship or curatorship
- •The patient (or a legal representative) formalizes his/her opposition for the study
- •It is impossible to correctly inform the patient
- •The patient is pregnant, parturient, or breastfeeding
- •The patient has a contraindication for a treatment used in this study
- •The patient's initial electrocardiogram indicates an ST segment elevation
结局指标
主要结局
Blood copeptin concentration (pmol/l)
时间窗: Day 0, in the ambulance
Final diagnosis of ACS non ST + (yes/no)
时间窗: Day 28
Blood troponin HS concentration (µg/L)
时间窗: Day 0, in the ambulance
次要结局
- Blood troponin HS concentration (µg/L)(Day 0, 3 hours after arrival in the emergency department)
- Time spent by ambulance staff at the patient's place of residence(Day 0)
- Distance (km) between the hospital and the patient's place of residence(Day 28)
- Would you leave the patient at home if both copeptin and troponin tests were negative?(Day O (in the ambulance))
- Hospital costs (€) associated with avoidable services(Day 28)
- Mortality(Day 28)
- Presence/absence of another diagnosis(Day 28)
- Number of patients taken in charge that day by ambulance staff.(Day 0)