Deventilation dyspnoea in patients with Chronic Obstructive Pulmonary Disease after switching off from non-invasive ventilation.

Completed

• Conditions: chronic bronchitis; emphysema; 10024967

• Registration Number: NL-OMON50268
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

COPD patients with a NIV indication using chronic NIV
Symptoms of deventilation dyspnoea after an afternoon sleep (in 10 of the 20
patients)

Exclusion Criteria

- COPD exacerbation within 2 weeks preceding the study
- Modification of ventilation within 2 weeks preceding the study
- Having a poor compliance with NIV (usage of < 4 h/day)
- Having other disorders leading to respiratory failure (such as morbid
obesity, kyphoscoliosis, neuromuscular diseases, tuberculosis)
- Not being able to sleep 1.5 hour in the afternoon
- Having spinal injury, BMI>50, damaged or inflamed skin around the thorax or a
cardiac pacemaker or other implanted devices

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Knowledge about the changes occurring during NIV in patients with COPD with<br /><br>deventilation dyspnoea. The percent change in EELV, IC, respiratory muscle<br /><br>activity and PtcCO2 will be calculated for both groups and correlated with the<br /><br>degree of deventilation dyspnoea.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Validation of the use of EIT to determine the change in end-expiratory lung<br /><br>volume. This is validated by comparing the results of the EIT measurement with<br /><br>the results of the IC manoeuvre. </p><br>