Fitness for the Ageing Brain Study II

Not Applicable

Completed

• Conditions: Alzheimer's disease (AD); Neurological - Alzheimer's disease

• Registration Number: ACTRN12609000755235
• Lead Sponsor: The University of Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-09-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 230

Inclusion Criteria

Diagnosis of mild to moderate AD (Mini-Mental State Examination (MMSE) score greater and equal 10/30)
Contact with carer more than 10 hours per week who is willing to participate in trial
Community-dwelling
No unstable or lifethreatening medical condition
Geriatric Depression Scale (GDS) score 7 or less (= no significant depression)
Needs to understand spoken and written English
Needs to be able to attend visits to the National Ageing Research Institute (NARI)
No severe visual or hearing impairment
No presence of significant aphasia
No history of chronic alcohol abuse within the past 5 years
No medical condition that contraindicates physcial activity

Exclusion Criteria

Unstable or lifethreatening medical condition
GDS score greater/ equal than 7 (= significant depression)
Cannot understand spoken and written English
Cannot attend visits to NARI
Severe visual or hearing impairment
Presence of significant aphasia
History of chronic alcohol abuse within the past 5 years
Medical condition that contraindicates physcial activity

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognitive function. This was measured using the Alzheimer's Disease Assessment Scale - cognitive section (ADAS-cog).[6 months following randomisation]

Secondary Outcome Measures

Name	Time	Method
Behavioural and Psychological Symptoms (BPSD). This was measured using the Neuropsychiatric Inventory.[6 months following randomisation];Functional level. This was assessed using the Step Test for balance, the Timed-Up-and-Go Test for agility, the Sit-to-Stand Test for leg strength, Hand Grip Strength for arm strength and the 2-minute Walk Test for aerobic endurance. Function was also assessed using the Instrumental Activities of Daily Living Scale and the Katz Activities of Daily Living Scale.[6 months following randomisation];Quality of life of participant and carer. This was assessed using the Quality of Life in AD measure.[6 months following randomisation];Carer burden. This was measured using the Zarit Burden Interview.[6 months following randomisation]