Comparative Study Of Clonidine & Esmolol In Attenuation Of Hemodynamic Stress Response To Endotracheal Intubation
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- The primary aim of the study is to compare the efficacy of Clonidine and Esmolol in attenuation of hemodynamic stress response due to laryngoscopy and endotracheal intubation.
研究概览
简要总结
Laryngoscopy and endotracheal intubation violate the patient’s protective airway reflexes and invariably cause hemodynamic changes associated with increased heart rate, increased blood pressure and occasional disturbance in cardiac rhythm. Effective attenuation of the sympathoadrenal stress response is an important goal in anesthesiology. Clonidine is an alpha 2 receptor agonist, which acts by decreasing central sympathetic outflow, increasing the parasympathetic tone and by decreasing circulating noradrenaline concentration. Esmolol is a short-acting cardioselective beta blocker, which reduces heart rate, systolic blood pressure, ejection fraction and cardiac index but it maintains coronary perfusion pressure. In this study an attempt will be made to observe, assess and compare the efficacy of Clonidine and Esmolol, in attenuating the haemodynamic response following laryngoscopy and endotracheal intubation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- All
入选标准
- •Adult patients undergoing elective laparoscopic surgery
- •American Society Of Anesthesiologists Grade 1
- •Patients giving Informed Written, Valid consent.
排除标准
- •Age less than 18 years and more than 45 years
- •Known allergy to anaesthetic agents
- •History of substance abuse and current opioid use
- •Anticipated difficult intubation
- •Baseline pulse less than 60 beats per minute
- •Baseline systolic blood pressure less than 100 mm Hg
- •Surgery time exceeding 2 hours 9.
结局指标
主要结局
The primary aim of the study is to compare the efficacy of Clonidine and Esmolol in attenuation of hemodynamic stress response due to laryngoscopy and endotracheal intubation.
时间窗: Rate Pressure Product (RPP) will be recorded just after intubation
次要结局
- The secondary aim of the study is to compare the efficacy of Clonidine & Esmolol in attenuation of hemodynamic stress response during pneumoperitoneum.(Rate Pressure Product (RPP) will be recorded 5 minutes after pneumoperitoneum)
研究者
Subhashis Saha
KPC Medical College & Hospital