Pulmonary Protection of Transcutaneous Electrical Acupoint Stimulation in Gynecologic Laparoscopic Surgery
试验速览
- 阶段
- 1 期
- 状态
- 暂停
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- the change of blood pH
研究概览
简要总结
TEAS might protect against postoperative pulmonary such as ischemia-reperfusion injury (IRI) and atelectasis. We tested the hypothesis that transcutaneous electrical acupoint stimulation protects against postoperative pulmonary complications in patients who are receiving mechanical ventilation during general anesthesia for gynecologic laparoscopic surgery.
详细描述
Participants: 100 patients who underwent elective gynecologic laparoscopic surgery Methods: We recruited 100 patients who are planned for gynecologic laparoscopic surgery. Patients were enrolled from March 1, 2015. We randomly allocated patients into two groups: controlled group ( patients treated without transcutaneous electrical acupoint stimulation) and TEAS group (patients treated with TEAS on Feishu, Hegu, Chize half an hour before the surgery). Blood pH, Pco2, Po2 and oxygen saturation were measured by an automatic blood gas analyzer immediately after obtaining the samples from the aorta. Sample all the patients blood before and after the surgery. And then measure the level of TNF-α, IL-1β, and IL-6.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Aged from 65 to 75
- •The American Society of anesthesiologists (American Society of Anesthesiology, ASA) class Ⅱ ~ III
- •scheduled for gynecologic laparoscopic surgery under general anesthesia
排除标准
- •pre-existing lung or caridac disease
- •impaired kidney or liver function
- •history of bronchial asthma or chronic obstructive pulmonary disease
- •history of smoking
- •respiratory infection in the previous 2 weeks
- •preoperative use of bronchodilator, or a steroid
结局指标
主要结局
the change of blood pH
时间窗: intraoperative
the change of hemodynamic parameter MAP in mmHg
时间窗: intraoperative
the change of hemodynamic parameters HR in beat per minutes
时间窗: intraoperative
the change of blood SPO2 in percentage
时间窗: intraoperative
the change of blood PCO2 in mmHg
时间窗: intraoperative
the change of blood PO2 in mmHg
时间窗: intraoperative
次要结局
- post-operative pulmonary complications(in the first 5 days after surgery)
- the change of Plasma concentration of TNF-α in pg/mL(intraoperative)
- the change of plasma concentration of IL-1β(intraoperative)
研究者
Yanchao Yang
resident doctor
Shengjing Hospital