Search for Biomarkers in Human Glaucoma: Lymphocytes Alterations and Rate of Progression

Completed

• Conditions: Glaucoma, Open-Angle

• Registration Number: NCT00981422
• Lead Sponsor: University of Parma

Brief Summary

The aim of this study was to evaluate the lymphocyte phenotype in primary open- angle glaucoma (POAG) patients compared to healthy subjects of the same age, in order to confirm the importance of immune responses in glaucoma and the possible correlation to the severity of the disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-06
• Primary Completion: 2007-12
• Study Completion: 2008-06
• Status Verified: 2009-09
• Study First Submitted: 2009-09-21
• Study First Submitted QC: 2009-09-21
• Last Update Submitted: 2009-09-21
• Study First Posted: 2009-09-22
• Last Update Posted: 2009-09-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Clinical diagnosis of primary open-angle glaucoma
• age between 19 an 85 years old

Exclusion Criteria

• age less than 19 or more than 85 yrs
• positive history for (a) neurodegenerative diseases, (b) autoimmune diseases, (c) cancer, (d) viral infection and (e) diabetes, (f)systemic inflammation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
compare the lymphocyte phenotype of POAG patients to healthy subjects of the same age	the same day of bloodwithdrawal

Secondary Outcome Measures

Name	Time	Method
correlate the immunophenotype of POAG patients to the severity of disease	within 3 months after blood withdrawal

Trial Locations

Locations (1)

Azienda ospedaliera universitaria; 🇮🇹 Parma, Italy