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临床试验/NCT03656211
NCT03656211已完成不适用

Fertility After Diagnosis and Management of Acquired Uterine Arteriovenous Malformation

Rennes University Hospital1 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2017年10月2日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
15
试验地点
1
主要终点
Evaluation of fertility

研究概览

简要总结

Uterine arteriovenous malformations (UAVM) are short circuits between systemic arterial and venous networks within the uterus. They are congenital or acquired (in the course of an endo-uterine gesture such as curettage or interventions such as caesareans or myomectomies).

They can be manifested by severe metrorrhagia that can go as far as to put the patient's vital prognosis at risk.

There are no recommendations for the management of UAVM since this pathology is rare and therefore series are performed with few cases. If some of these UAVM disappear spontaneously after a therapeutic abstention, when the clinical context allows it, in case of symptomatic UAVM, a selective embolization with arteriography is often carried out to postpone the hysterectomy of hemostasis.

There are also more marginal management options such as Gonadotropin-Releasing Hormone agonists, methotrexate or curettage that are decided on a case by case basis depending on the symptoms and protocols of each medical team.

Regarding subsequent fertility and pregnancy outcomes after conservative treatment, the number of studies is even lower.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
Female
接受健康志愿者

入选标准

  • Major patient
  • Diagnosis of UAVM, symptomatic or not, between January 1st, 2000 and March 30th, 2017 confirmed by imagery performed at the Rennes University Hospital
  • Not against her participation in research

排除标准

  • Minor patient at the time of diagnosis
  • congenital UAVM
  • Uterine malformation
  • Patient under legal protection (guardianship, curatorship, safeguard of justice).

结局指标

主要结局

Evaluation of fertility

时间窗: At the time of inclusion

The telephone interview seeks to assess fertility for all patients diagnosed with symptomatic or non-symptomatic UAVM regardless of initial management.

次要结局

  • Side effects of treatments for UAVM(At the time of inclusion)
  • Pregnancy outcomes after UAVM(At the time of inclusion)
  • Term of delivery after UAVM(At the time of inclusion)
  • Complications of treatments for UAVM(At the time of inclusion)

研究者

发起方
Rennes University Hospital
申办方类型
Other
责任方
Sponsor

研究点 (1)

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