Serum leptin and lipid profile before and after Omega-3 supplementation fatty acid in neonates with IUGR: A randomized control trial
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- effects of Omega-3 fatty acid supplementation on serum leptin levels of IUGR neonates
研究概览
简要总结
Metabolic programming seems to be potentially reversible during a restricted postnatal critical period.Supplementation with omega - 3 fatty acid during this critical period can reverse the metabolic programming and improves the outcomes of IUGR neonates by its effect on serum leptin levels and lipid profile. This present study aims to assess the effect of omega -3 supplementation on serum leptin and lipid profile of neonates with IUGR.
Intervention : omega 3 supplementation 40mg/kg/day mixed in 10 ml of expresssed breast milk or formula milk
Control : no intervention
Serum leptin and lipid profile assesses after 4weeks
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 0.00 Day(s) 至 28.00 Day(s)（—）
- 性别
- All
入选标准
- •Full Term Neonate between thirty seven weeks to fourty one plus six weeks SGA Ponderal index less than two On full feeds.
排除标准
- •Preterm neonates Neonates who died before feeding is established neonates with congenital infection, with multiple congenital anomalies/malformation Neonates with Cholestasis.
结局指标
主要结局
effects of Omega-3 fatty acid supplementation on serum leptin levels of IUGR neonates
时间窗: At enrollment and at 4 week of supplementation
次要结局
- effects of omega 3 fatty acid supplementation on lipid profile and on anthropomertic measurements(lipid profile: at enrollment and after 4 weeks)
研究者
Dr Geeta Gathwala
PGIMS,Rohtak, 124001