“Measuring and Treating Corneal Eye Infections.â€

Recruiting

• Conditions: Other and unspecified superficialkeratitis without conjunctivitis,

• Registration Number: CTRI/2020/03/024211
• Lead Sponsor: National Eye Institute

Brief Summary

Imagingto improve the quality of microbial keratitis is an International,observational, case control study. The purpose of this study is to evaluate microbialkeratitis treatment efficacy using morphological and clinical features and tocreate a risk stratification scoring system based on modelling of quantifiedImaging morphology and clinical data to the primary outcome of best correctedvisual acuity at 90 days. We hypothesise that morphological and clinical features accurately riskstratify patients for corneal and visual outcomes

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-07
• Last Update Posted: 2022-05-01

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

• Inclusion Criteria for cases 1) All participants must be aged above 15yrs and must be able to consent.
• 2. Clinically significant microbial keratitis more than or equal to 2 mm Inclusion Criteria for controls 1) Non-infectious inflammatory keratitis, either immune mediated or contact lens related.
• 2. Patients could have had previous therapy by an outside provider.

Exclusion Criteria

1. All participants aged <15yrs 2) Pregnancy 3) Prior incisional corneal surgery 4) No light perception vision 5) Corneal perforation/impending perforation 6) Viral keratitis 7) Acanthamoeba Keratitis 8) Difficulty coordinating timely study visits 9) Inpatient status 10) Institutional status.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To bring a validated tools to identify at-risk patients and to monitor patients with corneal infections	90 days

Secondary Outcome Measures

Name	Time	Method
To predict 90-Day eye health outcomes and to predict types of Corneal infections with substantial diagnostic accuracy The long term goal is to improve the initial and ongoing treatment for patients with corneal infections	12 months

Trial Locations

Locations (1)

Aravind Eye Hospital and PG Institute of Ophthalmology; 🇮🇳 Madurai, TAMIL NADU, India

Aravind Eye Hospital and PG Institute of Ophthalmology

🇮🇳Madurai, TAMIL NADU, India

Dr N Venkatesh Prajna

Principal investigator

914524356312

prajna@aravind.org