A Survey Study On Participants Of Vyanga With Special Reference To Melasma And Randomized Comparative Trial With Intervention Of Mukhavyangaroga Nashaka Arka And Arjuna Twak Lepa

Phase 2

Conditions: Health Condition 1: L819- Disorder of pigmentation, unspecified

Registration Number: CTRI/2024/07/070469

Lead Sponsor: ational Institute of Ayurveda

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Subjects with Fitzpatrick skin types III, IV and V presenting with the classical signs and symptoms of Vyanga will be selected.

Female subjects of childbearing potential using a reliable form of contraception during the course of the study excluding oral contraceptive pills at the time of the study or in the past 6 months (intrauterine device or condoms) or female of nonchildbearing potential (hysterectomy, bilateral ovariectomy or tubal section/ligation)

Female subjects of childbearing potential with a negative urine pregnancy test before inclusion in the study Patient willing to follow up.

Exclusion Criteria

Pregnant women, nursing mothers

Subjects having known chronic, contagious infectious disease, such as active tuberculosis, hepatitis B or C, HIV

Subjects suffering from other pigmentation disorders

Subject having used any cosmetic depigmenting agent within 2 weeks prior to inclusion

Subjects who have used a topical or inhaled corticosteroid or systemic steroids within 1 month prior to inclusion in the study

Subjects having used topical tretinoin within 3 months or topical hydroquinone within 6 months prior to inclusion

Subjects with history of endocrinopathies

Hyperpigmentation caused since birth like nevus of ota.

Hyperpigmentation caused by tumor like malignant melanoma, Known case of any active skin malignancy

Vyanga along with other Kushtha roga to be excluded.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in mMASI –modified Melasma Area and Severity index in the patients of Vyanga (Melasma)Timepoint: Changes will be observed on day 0 and Day 60

Secondary Outcome Measures