NCT06696638招募中不适用
Physiological Effects of Lung Impedance Tomography-guided and Plat Pressure-guided Phigh During Airway Pressure Release Ventilation in Patients With Acute Respiratory Distress Syndrome
XiaoJing Zou,MD1 个研究点 分布在 1 个国家目标入组 26 人开始时间: 2025年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- The effects of Phigh guided by different methods on regional lung ventilation assessed by EIT
研究概览
简要总结
This study aims to investigate the effects of EIT-guided and Pplat-guided Phigh settings on regional ventilation and perfusion in ARDS patients during APRV, while also examining the impact of different Phigh settings on gas exchange, respiratory mechanics, and hemodynamics.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with ARDS according to the 2023 global new definition of ARDS.
- •Age ≥ 18 years.
排除标准
- •Severe chronic obstructive pulmonary disease, severe asthma, pulmonary bullae, pneumothorax, subcutaneous emphysema, mediastinal emphysema, etc. · Contraindications for EIT, such as chest wound dressing, pacemaker implantation, defibrillator use, etc.
- •Pulmonary interstitial disease.
- •Uncorrected shock of various types.
- •Intracranial hypertension.
- •Pregnant and postpartum women.
结局指标
主要结局
The effects of Phigh guided by different methods on regional lung ventilation assessed by EIT
时间窗: 1 Hour Post-Intervention
次要结局
- Global inhomogeneity assessed by electrical impedance tomography(1 Hour Post-Intervention)
- Center of ventilation assessed by electrical impedance tomography(1 Hour Post-Intervention)
- mean arterial pressure(1 Hour Post-Intervention)
- ventilation/perfusion matching assessed by EIT(1 Hour Post-Intervention)
- Respiratory system compliance(1 Hour Post-Intervention)
研究者
XiaoJing Zou,MD
Clinical Professor
Wuhan Union Hospital, China
研究点 (1)
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