Effect of an experimental drug in two different dose combination versus control drug alone for insertion of radial artery cannula using ultrasound

Completed

Conditions: Medical and Surgical,

Registration Number: CTRI/2021/11/037704

Lead Sponsor: All India Institute of Medical Sciences Patna

Brief Summary: Arterial cannulation is widely used in operating rooms, intensive care units, and emergency departments**.**Radial artery is the most common site of cannulation**.**Radial artery cannulation often requires multiple attempts, which are painful**.** We require methods that can increase first-pass success rate**.**Drugs like nitroglycerin cause significant vasodilation that may assist arterial cannulation and lignocaine is commonly used for analgesia**.** Combination of both these may improve success rates of painless radial artery cannulation significantly**.**

Not many studies have assessed effect of different doses of nitroglycerin for ultrasound guided radial artery cannulation in adults when combined with lignocaine**.**

Adding vasodilators like nitroglycerin to lignocaine may significantly increase first**-**attempt success rates**.**Comparable first pass success rates may be obtained with lower doses of nitroglycerin**.** Significant increase in the diameter & cross sectional area of radial artery after subcutaneous administration of nitroglycerin**.**

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 168

Inclusion Criteria

All adult patients admitted in Intensive Care Unit (ICU) or undergoing elective surgeries in Operating room at AIIMS Patna requiring radial artery cannulation.

Exclusion Criteria

Infection overlying the site, Absent pulse/poor circulation assessed by the modified Allenâ€™s test, Coagulopathy, Partial/full thickness burn, Vascular graft in upper extremity, any vascular disease.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To estimate the first-attempt success rate of radial artery cannulation.	5 minutes

Secondary Outcome Measures

Name	Time	Method
To compare the diameter & cross sectional area of radial artery before and after subcutaneous administration of drugs.	5 minutes
To estimate the overall success rate of radial artery cannulation.	5 minutes
To estimate the percentage of patients developing puncture site hematoma.	5 minutes
To compare the mean number of attempts of radial artery cannulation.

Trial Locations

Locations (1): All India Institute Of Medical Sciences Patna
🇮🇳
Patna, BIHAR, India
All India Institute Of Medical Sciences Patna
🇮🇳Patna, BIHAR, India
Saras Singh
Principal investigator
9788859989
drssarassingh@gmail.com