Assessment of the Efficacy of Microosteoperforations Versus Injectable Platelet-rich Fibrin During Orthodontic Leveling and Alignment of Mandibular Incisors

Not Applicable

• Conditions: Effect of Platelet Rich Fibrin Versus Microosteoperforation Compaed to Control Group Toothmovement
• Interventions: Procedure: MOPs with leveling and alignment; Biological: iprf

• Registration Number: NCT06498609
• Lead Sponsor: Al-Azhar University

Brief Summary

The aim of this prospective clinical study will be to compare the efficacy of micro osteoperforations versus injectable platelet-rich fibrin during orthodontic leveling and alignment of mandibular incisors.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-05
• Study First Submitted: 2024-07-07
• Study First Submitted QC: 2024-07-07
• Last Update Submitted: 2024-07-07
• Study First Posted: 2024-07-12
• Last Update Posted: 2024-07-12
• Study Start: 2024-08-01
• Primary Completion: 2024-11-01
• Study Completion: 2024-12-01

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

1. An age range from 15 to 25 years.
2. Participants who had a full set of permanent dentitions excluding the third molar.
3. Participants who had moderate crowding in the mandibular arch according to Little's irregularity index that necessitates non-extraction treatment in the mandibular arch.
4. Normal vertical facial proportions.
5. Participants who had good oral hygiene and no periodontal disease.
6. No systemic diseases or regular medication that could interfere and/or affect orthodontic teeth movement.
7. No evidence of craniofacial anomalies, such as clef lip and palate or previous history of trauma, bruxism, or parafunction.
8. No tooth size, shape, or root abnormalities visible on patient's radiographic records.

Exclusion Criteria

1. Previous orthodontic treatment.
2. Any skeletal dysplasia or craniofacial malformation.
3. Retained primary or missing permanent teeth in the anterior area, and any kind of tooth/root shape anomaly or history of trauma affecting the incisors.
4. Systemic diseases or regular use of medications that could interfere with OTM.
5. Patients with root resorption, impacted canines, or dental anomalies.
6. Poor oral hygiene and uncontrolled periodontal diseases.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Microosteoperforation	MOPs with leveling and alignment	MOPs with leveling and alignment that will be performed tow time according to standardized protocol
Injectable platelet rich fibrin	iprf	i-PRF with leveling and alignment that will be performed tow time according to standardized protocol

Primary Outcome Measures

Name	Time	Method
assessment of acceleration of leveling and alignment of mandibular incisors	post interventional at 4months	rate of leveling and alignment

Trial Locations

Locations (1)

Alazhar University; 🇪🇬 Cairo, Egypt