Identifying Pulmonary Hypertension Phenotype in Left Heart Disease Patients Undergoing Cardiac Surgery Using Echocardiographic Variables: A prospective observational study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- To identify the phenotype of pulmonary hypertension using echocardiography parameters in patients with left heart disease undergoing cardiac surgery.
研究概览
简要总结
Pulmonary hypertension is a common finding in patients with cardiovascular disease. Most of these patients have left heart disease (LHD) with pulmonary hypertension secondary to an increase in left ventricular filling pressure but normal pulmonary vascular resistance (PVR). Low mean pulmonary artery (PA) pressure, low peripheral resistance, and high compliance in the central large arteries characterize the normal pulmonary circulation, and together this causes little reflection of the pressure wave. On the other hand, in patients with pulmonary hypertension due to increased PVR, augmented pressure (AP) after peak flow due to an earlier and more pronounced pressure reflection has been observed
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Left heart surgeries.
排除标准
- •Poor TTE window
- •Contraindication to TEE probe insertion.
结局指标
主要结局
To identify the phenotype of pulmonary hypertension using echocardiography parameters in patients with left heart disease undergoing cardiac surgery.
时间窗: Echo will be done at baseline, before cardiopulmonary bypass, post cardiopulmonary bypass, in the ICU when inotropes are tapered and 3 months post surgery
次要结局
- 1. To assess the effects of the pulmonary hypertension phenotype on right ventricular function in patients with left heart disease undergoing cardiac surgery.(2. To find correlation among invasive and non -invasive methods in classifying the phenotypes.)
研究者
Dr Arshdeep Singh
PGIMER Chandigarh