Oral nystatin prophylaxis to prevent of candida colonization in premature infant with weigth less than 1500 gram in Neonatal Intensive care Unit

Phase 3

Recruiting

Conditions: candida colonization.
Neonatal candidiasis
P37.5

Registration Number: IRCT20201222049802N2

Lead Sponsor: Zanjan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 106

Inclusion Criteria

infants born in the first 72 hours of life
birth weight less than 1500gram
gestational age less than 32 weeks
who are hospitalized in the neonatal intensive care unit

Exclusion Criteria

severe abnormalities
chromosomal abnormalities
severe sepsis
Congenital heart disease
Intraventricular hemorrage
disseminated intravascular coagulation
Thrush
congenital disorders requiring surgery
Fungal infections proven by blood or urine culture require treatment with appropriate antifungal drugs such as amphotericinCommunity Verified icon
Parents' dissatisfaction with the infant's participation in the study

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gestetional age. Timepoint: Week. Method of measurement: The number of weeks that have elapsed since the last menstrual period.;Birth weight. Timepoint: Birth. Method of measurement: Weighing the baby.;Type of delivery(Natural vaginal delivery or cesarean section). Timepoint: at birth. Method of measurement: Get a history and file.;Premature rupture of the membrane. Timepoint: rupture of the membrane>18houres. Method of measurement: Get a history and file.;Use of broad-spectrum antibiotics (third-generation cephalosporins and carbapenems). Timepoint: One week after birth. Method of measurement: Get a history and file.;Receive invasive respiratory ventilation. Timepoint: One week after birth. Method of measurement: Get a history and file.;Oral culture and smear for fungi. Timepoint: one week after birth. Method of measurement: laboratory report.;Rectal culture and smear for fungi. Timepoint: One week after birth. Method of measurement: laboratory report.

Secondary Outcome Measures